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KMID : 0942820090080010003
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Journal of Korean Brain Tumor Society
2009 Volume.8 No. 1 p.3 ~ p.15
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Clinical Application of Anti-Epileptic Drugs in the Field of Neuro-Oncology
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Kim Young-Zoon
Yoo Heon
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Abstract
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Epileptic seizures are common in patients with brain tumor, even if the tumor is under control. Miltiple factors affect the mechanism of seizure in brain tumors, including changes of morphology, pH, ion level, amino acid, and enzyme in peritumoral brain tissue, role of glutaminergic N-methyl-D-aspartate(NMDA) receptor, damage of peritumoral brain immunology, and change of intercellular communication. Additionally, traditional anti-epileptic drug(AED) can cover only a few mechanisms of epileptogensis in brain tumors. Tumor progression or recurrence may make seizures reappear during AED. Owing to combined treatment modality with chemotherapy or other drugs, insufficient levels of AEDs have been reported in the many patients with brain tumor. Therefore, comprehensive understand about pathophysiology of epileptogensis in the brain tumor and drug interactions between AEDs and other drugs, which are widely used in the field of neurooncology, can give an aids to manage brain tumor related epilepsy.
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KEYWORD
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Brain tumor, Seizure, Antiepileptic drug, Cytochrome P450 enzyme, Pathophysiology
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